Purine Analogs as Feedback Inhibitors.

Purine Analogs as Feedback Inhibitors.

Summary Accumulation of ribotide of 5-amino-4-imidazole carboxamide (AICAR), excreted in the riboside form by a purine-requiring mutant of Escherichia coli, was inhibited by a number of structural analogs of purines. The most potent inhibitors were 6-thioguanine, 6-mercaptopurine, and 2,6-diaminopur...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1959-08, Vol.101 (4), p.641-643
Hauptverfasser: Gots, Joseph S., Gollub, Edith G.
Format: Artikel
Sprache:eng
Schlagworte:
Antimetabolites
Humans
Purines - antagonists & inhibitors
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Zusammenfassung:Summary Accumulation of ribotide of 5-amino-4-imidazole carboxamide (AICAR), excreted in the riboside form by a purine-requiring mutant of Escherichia coli, was inhibited by a number of structural analogs of purines. The most potent inhibitors were 6-thioguanine, 6-mercaptopurine, and 2,6-diaminopurine. The type of inhibition obtained suggests that the antimetabolites sufficiently resemble natural purines in structure to act as feedback inhibitors in biosynthetic control.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-101-25045