Purine Analogs as Feedback Inhibitors.

Purine Analogs as Feedback Inhibitors.

Summary Accumulation of ribotide of 5-amino-4-imidazole carboxamide (AICAR), excreted in the riboside form by a purine-requiring mutant of Escherichia coli, was inhibited by a number of structural analogs of purines. The most potent inhibitors were 6-thioguanine, 6-mercaptopurine, and 2,6-diaminopur...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1959-08, Vol.101 (4), p.641-643
Hauptverfasser: Gots, Joseph S., Gollub, Edith G.
Format: Artikel
Sprache:eng
Schlagworte:
Antimetabolites
Humans
Purines - antagonists & inhibitors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 643
container_issue 4
container_start_page 641
container_title Experimental biology and medicine (Maywood, N.J.)
container_volume 101
creator Gots, Joseph S.
Gollub, Edith G.
description Summary Accumulation of ribotide of 5-amino-4-imidazole carboxamide (AICAR), excreted in the riboside form by a purine-requiring mutant of Escherichia coli, was inhibited by a number of structural analogs of purines. The most potent inhibitors were 6-thioguanine, 6-mercaptopurine, and 2,6-diaminopurine. The type of inhibition obtained suggests that the antimetabolites sufficiently resemble natural purines in structure to act as feedback inhibitors in biosynthetic control.
doi_str_mv 10.3181/00379727-101-25045
format Article
fullrecord <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_pubmed_primary_13851426</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.3181_00379727-101-25045</sage_id><sourcerecordid>10.3181_00379727-101-25045</sourcerecordid><originalsourceid>FETCH-LOGICAL-c339t-c1cc3f9538ac5311fc7e5d4753922415a6801ad177c41da2eb684d56debcf8a3</originalsourceid><addsrcrecordid>eNp9j71OwzAURi0EoqXwAgwoE5tbX_9nrCoKlSrB0N1ybKektEllNwNvT9IUsTFd6eqcTzoIPQKZMtAwI4SpXFGFgQCmgnBxhcYgmMBM5vk1GvcA7okRuktpRwgIReUtGgHTAjiVY_T80caqDtm8tvtmmzKbsmUIvrDuK1vVn1VRnZqYpvfoprT7FB4ud4I2y5fN4g2v319Xi_kaO8byE3bgHCtzwbR1ggGUTgXhuRIsp5SDsFITsB6Uchy8paGQmnshfShcqS2bIDrMutikFENpjrE62PhtgJi-2fw2dw8w5-ZOehqkY1scgv9TLpEdMBuAZLfB7Jo2drHpv8kfix1dpQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Purine Analogs as Feedback Inhibitors.</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Gots, Joseph S. ; Gollub, Edith G.</creator><creatorcontrib>Gots, Joseph S. ; Gollub, Edith G.</creatorcontrib><description>Summary Accumulation of ribotide of 5-amino-4-imidazole carboxamide (AICAR), excreted in the riboside form by a purine-requiring mutant of Escherichia coli, was inhibited by a number of structural analogs of purines. The most potent inhibitors were 6-thioguanine, 6-mercaptopurine, and 2,6-diaminopurine. The type of inhibition obtained suggests that the antimetabolites sufficiently resemble natural purines in structure to act as feedback inhibitors in biosynthetic control.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-101-25045</identifier><identifier>PMID: 13851426</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Antimetabolites ; Humans ; Purines - antagonists &amp; inhibitors</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1959-08, Vol.101 (4), p.641-643</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-c1cc3f9538ac5311fc7e5d4753922415a6801ad177c41da2eb684d56debcf8a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13851426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gots, Joseph S.</creatorcontrib><creatorcontrib>Gollub, Edith G.</creatorcontrib><title>Purine Analogs as Feedback Inhibitors.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary Accumulation of ribotide of 5-amino-4-imidazole carboxamide (AICAR), excreted in the riboside form by a purine-requiring mutant of Escherichia coli, was inhibited by a number of structural analogs of purines. The most potent inhibitors were 6-thioguanine, 6-mercaptopurine, and 2,6-diaminopurine. The type of inhibition obtained suggests that the antimetabolites sufficiently resemble natural purines in structure to act as feedback inhibitors in biosynthetic control.</description><subject>Antimetabolites</subject><subject>Humans</subject><subject>Purines - antagonists &amp; inhibitors</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1959</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9j71OwzAURi0EoqXwAgwoE5tbX_9nrCoKlSrB0N1ybKektEllNwNvT9IUsTFd6eqcTzoIPQKZMtAwI4SpXFGFgQCmgnBxhcYgmMBM5vk1GvcA7okRuktpRwgIReUtGgHTAjiVY_T80caqDtm8tvtmmzKbsmUIvrDuK1vVn1VRnZqYpvfoprT7FB4ud4I2y5fN4g2v319Xi_kaO8byE3bgHCtzwbR1ggGUTgXhuRIsp5SDsFITsB6Uchy8paGQmnshfShcqS2bIDrMutikFENpjrE62PhtgJi-2fw2dw8w5-ZOehqkY1scgv9TLpEdMBuAZLfB7Jo2drHpv8kfix1dpQ</recordid><startdate>195908</startdate><enddate>195908</enddate><creator>Gots, Joseph S.</creator><creator>Gollub, Edith G.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>195908</creationdate><title>Purine Analogs as Feedback Inhibitors.</title><author>Gots, Joseph S. ; Gollub, Edith G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-c1cc3f9538ac5311fc7e5d4753922415a6801ad177c41da2eb684d56debcf8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1959</creationdate><topic>Antimetabolites</topic><topic>Humans</topic><topic>Purines - antagonists &amp; inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gots, Joseph S.</creatorcontrib><creatorcontrib>Gollub, Edith G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gots, Joseph S.</au><au>Gollub, Edith G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Purine Analogs as Feedback Inhibitors.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1959-08</date><risdate>1959</risdate><volume>101</volume><issue>4</issue><spage>641</spage><epage>643</epage><pages>641-643</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary Accumulation of ribotide of 5-amino-4-imidazole carboxamide (AICAR), excreted in the riboside form by a purine-requiring mutant of Escherichia coli, was inhibited by a number of structural analogs of purines. The most potent inhibitors were 6-thioguanine, 6-mercaptopurine, and 2,6-diaminopurine. The type of inhibition obtained suggests that the antimetabolites sufficiently resemble natural purines in structure to act as feedback inhibitors in biosynthetic control.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13851426</pmid><doi>10.3181/00379727-101-25045</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0037-9727
ispartof Experimental biology and medicine (Maywood, N.J.), 1959-08, Vol.101 (4), p.641-643
issn 0037-9727
1535-3702
1535-3699
language eng
recordid cdi_pubmed_primary_13851426
source MEDLINE; Alma/SFX Local Collection
subjects Antimetabolites
Humans
Purines - antagonists & inhibitors
title Purine Analogs as Feedback Inhibitors.
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T03%3A16%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-sage_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Purine%20Analogs%20as%20Feedback%20Inhibitors.&rft.jtitle=Experimental%20biology%20and%20medicine%20(Maywood,%20N.J.)&rft.au=Gots,%20Joseph%20S.&rft.date=1959-08&rft.volume=101&rft.issue=4&rft.spage=641&rft.epage=643&rft.pages=641-643&rft.issn=0037-9727&rft.eissn=1535-3699&rft_id=info:doi/10.3181/00379727-101-25045&rft_dat=%3Csage_cross%3E10.3181_00379727-101-25045%3C/sage_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/13851426&rft_sage_id=10.3181_00379727-101-25045&rfr_iscdi=true