Isolation and synthesis of a new bio-antimutagen, petasiphenol, from scapes of Petasites japonicum

A new bio-antimutagen, petasiphenol [3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate] (1) was isolated from scapes of Petasites japonicum (AD 50 =95μg/ml against UV-induced mutagenic E. coli WP2 B/r Trp − . Petasiphenol (1) and its isomer (2) were synthesized. The activity of 1 was observed in the pres...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1992, Vol.56 (11), p.1773-1775
Hauptverfasser:	Iriye, R. (Shinshu Univ., Minamiminowa, Nagano (Japan). Faculty of Agriculture), Furukawa, K, Nishida, R, Kim, C, Fukami, H
Format:	Artikel
Sprache:	eng
Schlagworte:	ANTIMUTAGENE Antimutagenic Agents - chemical synthesis Antimutagenic Agents - isolation & purification Antimutagenic Agents - pharmacology ANTIMUTAGENO ANTIMUTAGENS Biological and medical sciences Biotechnology Caffeic Acids - chemical synthesis Caffeic Acids - isolation & purification Caffeic Acids - pharmacology CHEMICAL SYNTHESIS COMPOSE PHENOLIQUE COMPUESTOS FENOLICOS Escherichia coli - drug effects Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Isomerism Mutation - drug effects Other active biomolecules PETASITES PHENOLIC COMPOUNDS Plants, Medicinal - chemistry Production of active biomolecules SINTESIS QUIMICA SYNTHESE CHIMIQUE
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Zusammenfassung:	A new bio-antimutagen, petasiphenol [3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate] (1) was isolated from scapes of Petasites japonicum (AD 50 =95μg/ml against UV-induced mutagenic E. coli WP2 B/r Trp − . Petasiphenol (1) and its isomer (2) were synthesized. The activity of 1 was observed in the presence of soybean oil (glyceride), although the isomer (2) did not show any activity in doses up to 300, μg/ml.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.56.1773