DNA Damage Induced by Hypocrellin-A Photosensitization

Hypocrellin-A (HC-A) isolated from Hypocrellia bambusae Sacc., is a new and effective photosensitizer. Illumination of sarcoma 180 cells with visible light in the presence of HC-A leads to a decrease in cell viability and 3H-TdR incorporation, causes DNA strand breakage, and results in the selective...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of radiation biology 1992, Vol.61 (2), p.213-219
Hauptverfasser:	Cao, Eh-Hua, Xin, Shu-Min, Cheng, Long-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological effects of radiation Cell Division - drug effects DNA Damage DNA, Single-Stranded - drug effects Drugs, Chinese Herbal - pharmacology Fundamental and applied biological sciences. Psychology Perylene - analogs & derivatives Perylene - pharmacology Photolysis Quinones - pharmacology Radiation-Sensitizing Agents - pharmacology Radiosensitizing agents. Photosensitizing agents. Thermosensitizing agents Space life sciences Tissues, organs and organisms biophysics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Hypocrellin-A (HC-A) isolated from Hypocrellia bambusae Sacc., is a new and effective photosensitizer. Illumination of sarcoma 180 cells with visible light in the presence of HC-A leads to a decrease in cell viability and 3H-TdR incorporation, causes DNA strand breakage, and results in the selective destruction of guanine moieties in DNA. HC-A photosensitization causes an increase in the θ260/θ280 ratio in the circular dichroism spectra of DNA in vitro. Of the four usual 2′-deoxynucleotides illuminated in the presence of HC-A only 2′-deoxyguanylic acid was destroyed.
ISSN:	0955-3002 1362-3095
DOI:	10.1080/09553009214550841