Neurological toxicity of amiodarone. 5 case reports

Five patients developed neurological adverse effects as they were treated with amiodarone for 2 to 18 months. The daily maintenance dose did not exceed 400 mg. The neurological manifestations included tremor, ataxia, peripheral neuropathy, dyskinesia, myoclonic jerks, extrapyramidal hypertony, and a...

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Veröffentlicht in:	La revue de medecine interne 1992-11, Vol.13 (6), p.419
Hauptverfasser:	Arnaud, A, Neau, J P, Rivasseau-Jonveaux, T, Marechaud, R, Gil, R
Format:	Artikel
Sprache:	fre
Schlagworte:	Age Factors Aged Aged, 80 and over Alcoholism - complications Amiodarone - administration & dosage Amiodarone - adverse effects Diabetes Complications Female Humans Male Middle Aged Nervous System Diseases - chemically induced Nervous System Diseases - epidemiology Renal Insufficiency - complications Risk Factors Time Factors
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Zusammenfassung:	Five patients developed neurological adverse effects as they were treated with amiodarone for 2 to 18 months. The daily maintenance dose did not exceed 400 mg. The neurological manifestations included tremor, ataxia, peripheral neuropathy, dyskinesia, myoclonic jerks, extrapyramidal hypertony, and altered mental status. These side effects resolved within 3 days to 3 months after amiodarone withdrawal. Advanced age, renal failure, diabetes mellitus, and alcoholism seemed to be risk factors for development of amiodarone neurotoxicity. Both peripheral and central nervous systems are involved in these amiodarone-induced complications.
ISSN:	0248-8663