Asymmetric hydrogenation of a 4,4-diaryl-3-butenoate; a novel approach to sertraline

Asymmetric hydrogenation of a 4,4-diaryl-3-butenoate; a novel approach to sertraline

The asymmetric hydrogenation of a selectively crystallised (E)-4,4-diaryl-3-butenoate with a rhodium-PhanePhos catalyst is described, providing an intermediate to the antidepressant sertraline.

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Veröffentlicht in:Organic & biomolecular chemistry 2003-04, Vol.1 (7), p.1094
Hauptverfasser: Boulton, Lee T, Lennon, Ian C, McCague, Raymond
Format: Artikel
Sprache:eng
Schlagworte:
Antidepressive Agents - chemical synthesis
Antidepressive Agents - chemistry
Butyrates - chemistry
Catalysis
Hydrogenation
Molecular Structure
Rhodium - chemistry
Sertraline - chemical synthesis
Sertraline - chemistry
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Beschreibung
Zusammenfassung:The asymmetric hydrogenation of a selectively crystallised (E)-4,4-diaryl-3-butenoate with a rhodium-PhanePhos catalyst is described, providing an intermediate to the antidepressant sertraline.
ISSN:1477-0520
DOI:10.1039/b301175p