Dithranol reaction with nitroxide radicals in DMSO, a HPLC study

Dithranol (1,8-dihydroxy-9-anthrone), an efficient drug for the topical treatment of psoriasis undergoes a complex chemical transformation after topical application. An absorption phase HPLC method has been developed and validated to follow the appearance of its oxidative products in a DMSO solution...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmazie 2003-07, Vol.58 (7), p.475-479
Hauptverfasser:	Ferlan, A., Pečar, S., Schara, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthralin - chemistry Biological and medical sciences Calibration Chemistry Chromatography, High Pressure Liquid Dimethyl Sulfoxide - chemistry Exact sciences and technology Free Radicals General and physical chemistry Liquid-solid equilibria Medical sciences Nitrogen Oxides - chemistry Oxidation-Reduction Pharmacology. Drug treatments Phase equilibria Reference Standards Skin, nail, hair, dermoskeleton Solvents Spectrophotometry, Ultraviolet
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Dithranol (1,8-dihydroxy-9-anthrone), an efficient drug for the topical treatment of psoriasis undergoes a complex chemical transformation after topical application. An absorption phase HPLC method has been developed and validated to follow the appearance of its oxidative products in a DMSO solution. In DMSO solution dithranol, chrysazin, and biantrone were monitored simultaneously by HPLC during autooxidation process, as well as in the presence of nitroxide radicals which increase the reaction rate. The kinetics of the very early stage of dithranol transformation is presented for the first time and discussed. Two unknown dithranol-derived intermediates were found and partially characterised.
ISSN:	0031-7144