Neurologic deterioration in a child with Wilson's disease on penicillamine therapy

Penicillamine is the standard therapy for Wilson's disease in children. We report an 8-year-old-girl with liver disease due to Wilson's disease who developed extrapyramidal symptoms following administration of penicillamine. Symptoms resolved within 20 hours of stopping the drug but recurr...

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Veröffentlicht in:	Indian journal of gastroenterology 2003-05, Vol.22 (3), p.104
Hauptverfasser:	Paul, Alexander Chandran, Varkki, Sneha, Yohannan, Nisha B, Eapen, C E, Chandy, George, Raghupathy, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Chelating Agents - adverse effects Child Dose-Response Relationship, Drug Female Hepatolenticular Degeneration - drug therapy Humans Neurodegenerative Diseases - chemically induced Penicillamine - adverse effects Syndrome
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Zusammenfassung:	Penicillamine is the standard therapy for Wilson's disease in children. We report an 8-year-old-girl with liver disease due to Wilson's disease who developed extrapyramidal symptoms following administration of penicillamine. Symptoms resolved within 20 hours of stopping the drug but recurred within 24 hours when gradually increasing small doses were recommenced.
ISSN:	0254-8860