Bronchoconstriction and pulmonary hypertension during abortion induced by 15-methyl-prostaglandin F2alpha

Patients have experienced severe breathlessness during second trimester abortion initiated by the intramuscular injection of 15-methyl-prostaglandin F2alpha (15-me-PGF2alpha). In four healthy women given 400 mug of 15-me-PGF2alpha to induce abortion, pulmonary function tests showed reductions in art...

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Veröffentlicht in:	The American journal of medicine 1976-04, Vol.60 (4), p.556
Hauptverfasser:	Weir, E K, Greer, B E, Smith, S C, Silvers, G W, Droegemueller, W, Reeves, J T, Grover, R F
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Induced - adverse effects Adolescent Adult Blood Cell Count Blood Pressure - drug effects Bronchial Diseases - blood Bronchial Diseases - chemically induced Bronchial Diseases - physiopathology Carbon Dioxide - blood Female Forced Expiratory Flow Rates Functional Residual Capacity Humans Hypertension, Pulmonary - blood Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - physiopathology Maximal Midexpiratory Flow Rate Oxygen - blood Pregnancy Pregnancy Trimester, Second Prostaglandins F - adverse effects Prostaglandins F - pharmacology Prostaglandins F - therapeutic use Pulmonary Diffusing Capacity Vital Capacity - drug effects
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Zusammenfassung:	Patients have experienced severe breathlessness during second trimester abortion initiated by the intramuscular injection of 15-methyl-prostaglandin F2alpha (15-me-PGF2alpha). In four healthy women given 400 mug of 15-me-PGF2alpha to induce abortion, pulmonary function tests showed reductions in arterial oxygen tension, maximum expired air flow and vital capacity. Residual lung volume and the slope of phase III of the closing volume curves increased.
ISSN:	0002-9343
DOI:	10.1016/0002-9343(76)90723-3