Paraoxonase and other coronary risk factors in a community-based cohort

Paraoxonase and other coronary risk factors in a community-based cohort

Oxidative damage to circulating lipids and vascular tissues contributes to the initiation and progression of atherosclerosis. High density lipoprotein provides protection from atherosclerosis and the enzyme paraoxonase may contribute to this effect. The aim of the present study was to examine the tr...

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Veröffentlicht in:Redox report : communications in free radical research 2002-01, Vol.7 (5), p.304-307
Hauptverfasser: Cohen, Jacob, Jenkins, Alicia J., Karschimkus, Connie, Qing, Su, Lee, Chee Teik, O'Dea, Kerin, Best, James D., Rowley, Kevin G.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Aged, 80 and over
Arteriosclerosis - diagnosis
Arteriosclerosis - metabolism
Arteriosclerosis - pathology
Aryldialkylphosphatase
Australia
Carboxylic Ester Hydrolases - blood
Carotenoids - blood
Cohort Studies
Diabetes Complications
Diet
Esterases - blood
Female
Humans
Lipoproteins, HDL - metabolism
Male
Mass Screening
Middle Aged
Risk Factors
Smoking
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Zusammenfassung:Oxidative damage to circulating lipids and vascular tissues contributes to the initiation and progression of atherosclerosis. High density lipoprotein provides protection from atherosclerosis and the enzyme paraoxonase may contribute to this effect. The aim of the present study was to examine the trends in paraoxonase activity during the course of a community-directed life-style intervention, and relationships of paraoxonase activity to other coronary heart disease risk factors, in a cohort of Australian Aboriginal people.
ISSN:1351-0002
1743-2928
DOI:10.1179/135100002125000848