Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: Trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins

The expression level of mRNAs for cytochrome P450 (CYP) 1A1 and 1B1 in freshly prepared white cells from 72 subjects exposed to dioxins at waste incinerators was investigated. The amounts of CYP1B1 mRNA ranged from 0.16 to 671 molecules/10(7) molecules of 18S rRNA, whereas the amounts of CYP1A1 mRNA...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2003-03, Vol.12 (3), p.219-222
Hauptverfasser:	TOIDE, Kenji, YAMAZAKI, Hiroshi, NAGASHIMA, Rikako, ITOH, Keisuke, IWANO, Shunsuke, TAKAHASHI, Yoshiki, WATANABE, Shaw, KAMATAKI, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Aryl Hydrocarbon Hydroxylases - genetics Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1B1 Dioxins - adverse effects Enzyme Induction - drug effects Gene Expression Regulation, Enzymologic - drug effects Humans Incineration Japan Leukocytes - metabolism Medical sciences Occupational Exposure - adverse effects RNA, Messenger - genetics Tumors
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Zusammenfassung:	The expression level of mRNAs for cytochrome P450 (CYP) 1A1 and 1B1 in freshly prepared white cells from 72 subjects exposed to dioxins at waste incinerators was investigated. The amounts of CYP1B1 mRNA ranged from 0.16 to 671 molecules/10(7) molecules of 18S rRNA, whereas the amounts of CYP1A1 mRNA were
ISSN:	1055-9965 1538-7755