Defibrinogenation Therapy for Idiopathic Sudden Sensorineural Hearing Loss in Comparison with High-dose Steroid Therapy

Objective--The efficacy of defibrinogenation therapy for idiopathic sudden sensorineural hearing loss was studied in comparison with high-dose steroid therapy. Material and methods--Eighty-eight consecutive patients with hearing levels >40 dB and who had suffered hearing loss for ≤30 days were en...

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Veröffentlicht in:	Acta oto-laryngologica 2003, Vol.123 (1), p.46-50
Hauptverfasser:	Suzuki, Hideaki, Furukawa, Masayuki, Kumagai, Masaki, Takahashi, Etsu, Matsuura, Kazuto, Katori, Yukio, Shimomura, Akira, Kobayashi, Toshimitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Aged Aged, 80 and over Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - adverse effects Audiometry, Pure-Tone Auditory Threshold Batroxobin Batroxobin - administration & dosage Batroxobin - adverse effects Biological and medical sciences Child Defibrinogenation Therapy Dose-Response Relationship, Drug Drug Administration Schedule Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ent. Stomatology Female Fibrinogen - metabolism Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - adverse effects Hearing Loss, Sudden - blood Hearing Loss, Sudden - drug therapy High-dose Steroid Therapy Humans Idiopathic Sudden Sensorineural Hearing Loss Infusions, Intravenous Male Medical sciences Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Prednisolone - administration & dosage Prednisolone - adverse effects Treatment Outcome
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Zusammenfassung:	Objective--The efficacy of defibrinogenation therapy for idiopathic sudden sensorineural hearing loss was studied in comparison with high-dose steroid therapy. Material and methods--Eighty-eight consecutive patients with hearing levels >40 dB and who had suffered hearing loss for ≤30 days were enrolled: 40 patients for high-dose steroid therapy (PSL group) and 48 for defibrinogenation therapy (BX group). Hearing recovery was evaluated by grade assessment and by the improvement in hearing compared to the unaffected contralateral ear. Results--The overall hearing outcomes of the two groups were roughly equivalent. However, with regard to patients with initial hearing levels
ISSN:	0001-6489 1651-2251
DOI:	10.1080/0036554021000028082