Adjuvant activity of alum in inducing antigen specific IgE antibodies in BALB/c mice: A reevaluation

The IgE production was compared in the presence and absence of aluminum hydroxide gel (alum). Without alum, the IgE production was induced within a suitable range of the antigen dosage; however, alum enhanced it. Alum did not affect the minimum requirement for the antigen dosage, indicating that alu...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2003-01, Vol.67 (1), p.166-169
Hauptverfasser:	Yamanishi, R. (Tokushima Univ. (Japan). School of Medicine), Yusa, I, Bando, N, Terao, J
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvant ADJUVANTS Adjuvants, Immunologic alum Alum Compounds - pharmacology ALUMINIUM Animals Antibody Specificity antigen dosage ANTIGENS Biological and medical sciences Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology IgE Immunoglobulin E - analysis Immunoglobulin E - biosynthesis Immunoglobulin G - analysis Immunoglobulin G - biosynthesis IMMUNOGLOBULINS MICE Mice, Inbred BALB C Ovalbumin - immunology Passive Cutaneous Anaphylaxis
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Zusammenfassung:	The IgE production was compared in the presence and absence of aluminum hydroxide gel (alum). Without alum, the IgE production was induced within a suitable range of the antigen dosage; however, alum enhanced it. Alum did not affect the minimum requirement for the antigen dosage, indicating that alum may not take part in the efficiency of antigen presentation.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.67.166