Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-α or TNF-related apoptosis-inducing ligand in human cancer cell lines

Flavopiridol is one of the first cyclin-dependent kinase inhibitors undergoing clinical tests. We found that the combination treatment of flavopiridol (100-500 nM) with tumor necrosis factor (TNF)-alpha (10 ng/ml) induced a rapid and eminent apoptosis, 20 +/- 5% in 6-h treatment, in a human non-smal...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-02, Vol.63 (3), p.621-626
Hauptverfasser:	KIM, Dong-Myung, KOO, Sun-Young, JEON, Kiwan, MIN HYUNG KIM, LEE, Jinho, CHANG YONG HONG, JEONG, Shinwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins Biological and medical sciences Carcinoma, Small Cell - drug therapy Carcinoma, Small Cell - enzymology Carcinoma, Small Cell - pathology Caspase Inhibitors Caspases - metabolism Chemotherapy Colonic Neoplasms - drug therapy Colonic Neoplasms - enzymology Colonic Neoplasms - pathology Drug Screening Assays, Antitumor Drug Synergism Enzyme Activation - drug effects Fibroblasts - drug effects Flavonoids - administration & dosage Humans Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - pathology Medical sciences Membrane Glycoproteins - administration & dosage NF-kappa B - antagonists & inhibitors Pharmacology. Drug treatments Piperidines - administration & dosage Rats Recombinant Proteins - administration & dosage TNF-Related Apoptosis-Inducing Ligand Transcriptional Activation - drug effects Tumor Cells, Cultured Tumor Necrosis Factor-alpha - administration & dosage
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