Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention

Mutations in the adenomatous polyposis coli (APC) gene, which initiate almost all human colon cancers, directly target the proto-oncogene, c-myc, by elevating beta-catenin/T-cell factor (TCF) signaling. We have shown that agents ascribed chemopreventive activity for colon cancer in fact also stimula...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002-11, Vol.62 (21), p.6006-6010
Hauptverfasser:	WILSON, Andrew J, VELCICH, Anna, ARANGO, Diego, KURLAND, Amy R, SHENOY, Shailesh M, PEZO, Rossanna C, LEVSKY, Jeffrey M, SINGER, Robert H, AUGENLICHT, Leonard H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticarcinogenic Agents - pharmacology Biological and medical sciences Butyrates - pharmacology Carcinogenesis, carcinogens and anticarcinogens Chemical agents Colonic Neoplasms - genetics Colonic Neoplasms - prevention & control Dihydroxycholecalciferols - pharmacology DNA Probes Drug Interactions Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Gene Silencing - drug effects Genes, myc - drug effects Genes, myc - genetics Genetic Predisposition to Disease Humans Medical sciences RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Messenger - metabolism Sulindac - pharmacology Transcription, Genetic - drug effects Transcription, Genetic - genetics Tumors
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