Interferon induction by viruses and polynucleotides: a differential effect of comptothecin

Interferon induction by viruses and polynucleotides: a differential effect of comptothecin

The plant alkaloid comptothecin inhibits interferon production induced by Newcastle disease virus (NDV) or ultraviolet-irradiated NDV in chick and human cells, and by Sindbis virus in chick cells. It has no effect on interferon production induced by poly (rI).poly(rC) in chick and human cells. No ef...

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Veröffentlicht in:Journal of general virology 1975-12, Vol.29 (3), p.297
Hauptverfasser: Atherton, K T, Burke, D C
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Camptothecin - pharmacology
Chick Embryo
Culture Techniques
Humans
Interferons - biosynthesis
Newcastle disease virus - growth & development
Newcastle disease virus - radiation effects
Poly I-C - pharmacology
Protein Biosynthesis
Radiation Effects
RNA - biosynthesis
Sindbis Virus - growth & development
Ultraviolet Rays
Virus Replication - drug effects
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Zusammenfassung:The plant alkaloid comptothecin inhibits interferon production induced by Newcastle disease virus (NDV) or ultraviolet-irradiated NDV in chick and human cells, and by Sindbis virus in chick cells. It has no effect on interferon production induced by poly (rI).poly(rC) in chick and human cells. No effect of comptothecin could be detected on the multiplication of NDV, and it is concluded that the inhibition reflects a difference between interferon induction by viruses and by polynucleotides.
ISSN:0022-1317