Estrogen increases iNOS expression in the ovine coronary artery

Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0526 Estrogen is believed to protect postmenopausal women from coronary vascular disease, in part by increasing production of nitric oxide (NO). In this study, we investigated the possibili...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2002-09, Vol.283 (3), p.H1169-H1180
Hauptverfasser: Mershon, John L, Baker, R. Scott, Clark, Kenneth E
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Sprache:eng
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Zusammenfassung:Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0526 Estrogen is believed to protect postmenopausal women from coronary vascular disease, in part by increasing production of nitric oxide (NO). In this study, we investigated the possibility that transcriptional activation of inducible NO synthase (iNOS) is responsible for a component of the estrogen-induced increase in coronary blood flow. Twenty-two ewes were instrumented with Doppler flow probes on their left circumflex coronary and pulmonary arteries. Nine ewes received 17 -estradiol (1 µg/kg), and the coronary vascular response was followed for 16 h. Estradiol significantly increased coronary blood flow by 22 ± 4% over baseline and the peak response occurred at 2 h ( P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00397.2000