Genetics of lymphedema: from Milroy's disease to cancer investigations
New insight has recently been obtained into the molecular mechanisms regulating lymphatic development and function during embryogenesis. VEGF-C and D ligands have been shown to stimulate lymphangiogenesis and their lymphatic-specific receptor VEGFR-3 is linked to the human congenital and hereditary...
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| Veröffentlicht in: | La revue de medecine interne 2002-06, Vol.23 Suppl 3, p.379s |
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| container_start_page | 379s |
| container_title | La revue de medecine interne |
| container_volume | 23 Suppl 3 |
| creator | Quéré, I Coupé, M Soulier-Sotto, V Evrard-Bras, M Laroche, J P Janbon, C |
| description | New insight has recently been obtained into the molecular mechanisms regulating lymphatic development and function during embryogenesis. VEGF-C and D ligands have been shown to stimulate lymphangiogenesis and their lymphatic-specific receptor VEGFR-3 is linked to the human congenital and hereditary lymphedema in humans. Above all, new focus on lymphatic endothelial cells gives opportunities for developing innovative therapies for lymphedema and cancer metastasis. |
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VEGF-C and D ligands have been shown to stimulate lymphangiogenesis and their lymphatic-specific receptor VEGFR-3 is linked to the human congenital and hereditary lymphedema in humans. 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VEGF-C and D ligands have been shown to stimulate lymphangiogenesis and their lymphatic-specific receptor VEGFR-3 is linked to the human congenital and hereditary lymphedema in humans. Above all, new focus on lymphatic endothelial cells gives opportunities for developing innovative therapies for lymphedema and cancer metastasis.</abstract><cop>France</cop><pmid>12162200</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0248-8663 |
| ispartof | La revue de medecine interne, 2002-06, Vol.23 Suppl 3, p.379s |
| issn | 0248-8663 |
| language | fre |
| recordid | cdi_pubmed_primary_12162200 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Endothelial Growth Factors - genetics Endothelial Growth Factors - pharmacology Humans Ligands Lymph Lymphedema - genetics Lymphedema - physiopathology Neoplasm Metastasis Neoplasms - complications Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor D |
| title | Genetics of lymphedema: from Milroy's disease to cancer investigations |
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