Genetics of lymphedema: from Milroy's disease to cancer investigations

Genetics of lymphedema: from Milroy's disease to cancer investigations

New insight has recently been obtained into the molecular mechanisms regulating lymphatic development and function during embryogenesis. VEGF-C and D ligands have been shown to stimulate lymphangiogenesis and their lymphatic-specific receptor VEGFR-3 is linked to the human congenital and hereditary...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:La revue de medecine interne 2002-06, Vol.23 Suppl 3, p.379s
Hauptverfasser: Quéré, I, Coupé, M, Soulier-Sotto, V, Evrard-Bras, M, Laroche, J P, Janbon, C
Format: Artikel
Sprache:fre
Schlagworte:
Endothelial Growth Factors - genetics
Endothelial Growth Factors - pharmacology
Humans
Ligands
Lymph
Lymphedema - genetics
Lymphedema - physiopathology
Neoplasm Metastasis
Neoplasms - complications
Vascular Endothelial Growth Factor C
Vascular Endothelial Growth Factor D
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:New insight has recently been obtained into the molecular mechanisms regulating lymphatic development and function during embryogenesis. VEGF-C and D ligands have been shown to stimulate lymphangiogenesis and their lymphatic-specific receptor VEGFR-3 is linked to the human congenital and hereditary lymphedema in humans. Above all, new focus on lymphatic endothelial cells gives opportunities for developing innovative therapies for lymphedema and cancer metastasis.
ISSN:0248-8663