Effect of subchronic ethanol treatment on plasma and cerebrospinal fluid leptin levels in rats selectively bred for high and low alcohol preference

The effect of 5-week voluntary ethanol (EtOH) intake on plasma and cerebrospinal fluid (CSF) leptin levels was determined in adult male Warsaw high EtOH preferring (WHP) and low preferring (WLP) rats. EtOH treatment led to a decrease in leptin CSF concentration in WHP rats when compared to EtOH-naiv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Polish journal of pharmacology 2002-03, Vol.54 (2), p.127
Hauptverfasser:	Mikołajczak, Przemysław, Okulicz-Kozaryn, Irena, Kamińska, Ewa, Wiktorowicz, Krzysztof, Leśniewska, Kinga, Dyr, Wanda, Kostowski, Wojciech
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking - blood Alcohol Drinking - cerebrospinal fluid Alcohol Drinking - genetics Alcoholism - blood Alcoholism - cerebrospinal fluid Alcoholism - genetics Animals Body Weight - drug effects Ethanol - pharmacology Leptin - blood Leptin - cerebrospinal fluid Male Rats Rats, Wistar
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The effect of 5-week voluntary ethanol (EtOH) intake on plasma and cerebrospinal fluid (CSF) leptin levels was determined in adult male Warsaw high EtOH preferring (WHP) and low preferring (WLP) rats. EtOH treatment led to a decrease in leptin CSF concentration in WHP rats when compared to EtOH-naive WHP and control Wistar rats. On the contrary, in EtOH-treated WLP rats, both plasma and CSF leptin levels were increased in comparison with EtOH-naive animals. It can be concluded that EtOH treatment led to different response expressed especially by CSF leptin levels in WHP and WLP animals and it may be related to their genetic predisposition.
ISSN:	1230-6002