Bioenergetic remodeling of heart during treatment of spontaneously hypertensive rats with enalapril

Departments of 1 Biology and 2 Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada K7L 3N6 We used spontaneously hypertensive rats to study remodeling of cardiac bioenergetics associated with changes in blood pressure. Blood pressure was manipulated with aggressive antihypertensive treatment combining low dietary salt and the angiotensin-converting enzyme inhibitor enalapril. Successive cycles of 2 wk on, 2 wk off treatment led to rapid, reversible changes in left ventricular (LV) mass (30% change in