Design and Synthesis of Bis 1-Chloromethyl-5-hydroxy-1,2- dihydro-3H-benz[e]indole (s eco-CBI)-Pyrrole Polyamide Conjugates

Design and Synthesis of Bis 1-Chloromethyl-5-hydroxy-1,2- dihydro-3H-benz[e]indole (s eco-CBI)-Pyrrole Polyamide Conjugates

The design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates (13, 17) as DNA minor groove binding agents are described.

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Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2002-05, Vol.4 (11), p.1851-1854
Hauptverfasser: Kumar, Rohtash, Lown, J. William
Format: Artikel
Sprache:eng
Schlagworte:
Acetylene - analogs & derivatives
Acetylene - chemistry
Aldehydes - chemistry
Animals
Antineoplastic Agents, Alkylating - chemical synthesis
Benzaldehydes - chemistry
Drug Design
Drug Screening Assays, Antitumor
Humans
Indicators and Reagents
Indoles - chemistry
Kinetics
Mice
Pyrroles - chemistry
Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:The design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates (13, 17) as DNA minor groove binding agents are described.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol020047k