Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on α-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats
The hepatoprotective effects of Ixeris laevigata Sch‐Bip. var. oldhami Kitam. (IL) were studied on cholestatic hepatitis induced by α‐naphthylisothiocyanate (ANIT, 100 mg/10 mL/kg, in olive oil, i.p.) and acute hepatitis induced by carbon tetrachloride (20% CCl4/olive oil, 1.5 mL/kg, i.p.) in rats....
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| Veröffentlicht in: | Phytotherapy research 2002-03, Vol.16 (S1), p.45-50 |
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| creator | Lu, Kuo-Liang Tsai, Chin-Chuan Ho, Li-Kang Lin, Chun-Ching Chang, Yuan-Shiun |
| description | The hepatoprotective effects of Ixeris laevigata Sch‐Bip. var. oldhami Kitam. (IL) were studied on cholestatic hepatitis induced by α‐naphthylisothiocyanate (ANIT, 100 mg/10 mL/kg, in olive oil, i.p.) and acute hepatitis induced by carbon tetrachloride (20% CCl4/olive oil, 1.5 mL/kg, i.p.) in rats. Hepatoprotective activity was monitored by estimating the serum transaminases levels and the histopathological changes in the livers of experimental rats. The pretreatment of animals with IL, extract (0.3–2.0 g/kg orally) significantly inhibited the acute elevation of serum transaminases, as well as the hepatotoxin‐induced histopathological changes in the livers of the experimental rats. Copyright © 2002 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.801 |
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(IL) were studied on cholestatic hepatitis induced by α‐naphthylisothiocyanate (ANIT, 100 mg/10 mL/kg, in olive oil, i.p.) and acute hepatitis induced by carbon tetrachloride (20% CCl4/olive oil, 1.5 mL/kg, i.p.) in rats. Hepatoprotective activity was monitored by estimating the serum transaminases levels and the histopathological changes in the livers of experimental rats. The pretreatment of animals with IL, extract (0.3–2.0 g/kg orally) significantly inhibited the acute elevation of serum transaminases, as well as the hepatotoxin‐induced histopathological changes in the livers of the experimental rats. Copyright © 2002 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.801</identifier><identifier>PMID: 11933139</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>1-Naphthylisothiocyanate - toxicity ; Animals ; carbon tetrachloride ; Carbon Tetrachloride - toxicity ; Chemical and Drug Induced Liver Injury - prevention & control ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - therapeutic use ; Drugs, Chinese Herbal - toxicity ; hepatoprotective ; Ixeris laevigata var. oldhami ; Liver - drug effects ; Liver - enzymology ; Liver - pathology ; Liver Function Tests ; Male ; Medicine, Chinese Traditional ; Mice ; Mice, Inbred ICR ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - therapeutic use ; Plant Extracts - toxicity ; Plants, Medicinal ; Rats ; Rats, Wistar ; Silymarin - administration & dosage ; Silymarin - pharmacology ; Silymarin - therapeutic use ; Taiwan ; α -naphthylisothiocyanate</subject><ispartof>Phytotherapy research, 2002-03, Vol.16 (S1), p.45-50</ispartof><rights>Copyright © 2002 John Wiley & Sons, Ltd.</rights><rights>Copyright 2002 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.801$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.801$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11933139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Kuo-Liang</creatorcontrib><creatorcontrib>Tsai, Chin-Chuan</creatorcontrib><creatorcontrib>Ho, Li-Kang</creatorcontrib><creatorcontrib>Lin, Chun-Ching</creatorcontrib><creatorcontrib>Chang, Yuan-Shiun</creatorcontrib><title>Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on α-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The hepatoprotective effects of Ixeris laevigata Sch‐Bip. var. oldhami Kitam. (IL) were studied on cholestatic hepatitis induced by α‐naphthylisothiocyanate (ANIT, 100 mg/10 mL/kg, in olive oil, i.p.) and acute hepatitis induced by carbon tetrachloride (20% CCl4/olive oil, 1.5 mL/kg, i.p.) in rats. Hepatoprotective activity was monitored by estimating the serum transaminases levels and the histopathological changes in the livers of experimental rats. The pretreatment of animals with IL, extract (0.3–2.0 g/kg orally) significantly inhibited the acute elevation of serum transaminases, as well as the hepatotoxin‐induced histopathological changes in the livers of the experimental rats. Copyright © 2002 John Wiley & Sons, Ltd.</description><subject>1-Naphthylisothiocyanate - toxicity</subject><subject>Animals</subject><subject>carbon tetrachloride</subject><subject>Carbon Tetrachloride - toxicity</subject><subject>Chemical and Drug Induced Liver Injury - prevention & control</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Drugs, Chinese Herbal - toxicity</subject><subject>hepatoprotective</subject><subject>Ixeris laevigata var. oldhami</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - pathology</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Medicine, Chinese Traditional</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Extracts - toxicity</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Silymarin - administration & dosage</subject><subject>Silymarin - pharmacology</subject><subject>Silymarin - therapeutic use</subject><subject>Taiwan</subject><subject>α -naphthylisothiocyanate</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkd1uEzEQhS0EoqEg3gD5Hjn12LvZ7CUKUCq1JarCz501sWdZtxtv5HXS7gPxAH0RnqmuAuXqjDSfRnPOYewtyClIqU62KU7nEp6xCci6FlBW-jmbyLoEUcD85xF7NQzXUspayeIlOwKotQZdT9jvZaQ9heT3xKlpyCbeNzy1xFfobzHwpu9u-Iactz4QP7uj6AfeIe39L0zI9xinvO9cixvP-8D_3IuA2za1Yyf80KfW93bEgIk4BsctxnWmEqWItu366B0JH9zOkuNodxnr8iuR-3C9i2MWHjENr9mLBruB3vzVY_bt86fV4os4_3p6tvhwLrwCDQKksnaNSjVyphAoO0QooFI16XVROi3zCOhqglIVZaMa0FVR4Uy5uXXK6mP27nB3u1tnz2Yb_QbjaP7llYH3B-DWdzT-30vzWIPJNZhcg1murrJkWhxoPyS6e6Ix3phZpavS_Lg8NYvLq4vl8vtHs9IPAhaNCg</recordid><startdate>200203</startdate><enddate>200203</enddate><creator>Lu, Kuo-Liang</creator><creator>Tsai, Chin-Chuan</creator><creator>Ho, Li-Kang</creator><creator>Lin, Chun-Ching</creator><creator>Chang, Yuan-Shiun</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200203</creationdate><title>Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on α-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats</title><author>Lu, Kuo-Liang ; Tsai, Chin-Chuan ; Ho, Li-Kang ; Lin, Chun-Ching ; Chang, Yuan-Shiun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2131-102ccba22f062a1e139a141729e3b45d307291ad9e15245f2f13747a62d8cd2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>1-Naphthylisothiocyanate - toxicity</topic><topic>Animals</topic><topic>carbon tetrachloride</topic><topic>Carbon Tetrachloride - toxicity</topic><topic>Chemical and Drug Induced Liver Injury - prevention & control</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Drugs, Chinese Herbal - toxicity</topic><topic>hepatoprotective</topic><topic>Ixeris laevigata var. oldhami</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - pathology</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Medicine, Chinese Traditional</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Extracts - toxicity</topic><topic>Plants, Medicinal</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Silymarin - administration & dosage</topic><topic>Silymarin - pharmacology</topic><topic>Silymarin - therapeutic use</topic><topic>Taiwan</topic><topic>α -naphthylisothiocyanate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Kuo-Liang</creatorcontrib><creatorcontrib>Tsai, Chin-Chuan</creatorcontrib><creatorcontrib>Ho, Li-Kang</creatorcontrib><creatorcontrib>Lin, Chun-Ching</creatorcontrib><creatorcontrib>Chang, Yuan-Shiun</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Kuo-Liang</au><au>Tsai, Chin-Chuan</au><au>Ho, Li-Kang</au><au>Lin, Chun-Ching</au><au>Chang, Yuan-Shiun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on α-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2002-03</date><risdate>2002</risdate><volume>16</volume><issue>S1</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The hepatoprotective effects of Ixeris laevigata Sch‐Bip. var. oldhami Kitam. (IL) were studied on cholestatic hepatitis induced by α‐naphthylisothiocyanate (ANIT, 100 mg/10 mL/kg, in olive oil, i.p.) and acute hepatitis induced by carbon tetrachloride (20% CCl4/olive oil, 1.5 mL/kg, i.p.) in rats. Hepatoprotective activity was monitored by estimating the serum transaminases levels and the histopathological changes in the livers of experimental rats. The pretreatment of animals with IL, extract (0.3–2.0 g/kg orally) significantly inhibited the acute elevation of serum transaminases, as well as the hepatotoxin‐induced histopathological changes in the livers of the experimental rats. Copyright © 2002 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>11933139</pmid><doi>10.1002/ptr.801</doi><tpages>6</tpages></addata></record> |
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| subjects | 1-Naphthylisothiocyanate - toxicity Animals carbon tetrachloride Carbon Tetrachloride - toxicity Chemical and Drug Induced Liver Injury - prevention & control Dose-Response Relationship, Drug Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - therapeutic use Drugs, Chinese Herbal - toxicity hepatoprotective Ixeris laevigata var. oldhami Liver - drug effects Liver - enzymology Liver - pathology Liver Function Tests Male Medicine, Chinese Traditional Mice Mice, Inbred ICR Phytotherapy Plant Extracts - administration & dosage Plant Extracts - therapeutic use Plant Extracts - toxicity Plants, Medicinal Rats Rats, Wistar Silymarin - administration & dosage Silymarin - pharmacology Silymarin - therapeutic use Taiwan α -naphthylisothiocyanate |
| title | Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on α-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats |
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