Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on α-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats

The hepatoprotective effects of Ixeris laevigata Sch‐Bip. var. oldhami Kitam. (IL) were studied on cholestatic hepatitis induced by α‐naphthylisothiocyanate (ANIT, 100 mg/10 mL/kg, in olive oil, i.p.) and acute hepatitis induced by carbon tetrachloride (20% CCl4/olive oil, 1.5 mL/kg, i.p.) in rats....

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Veröffentlicht in:	Phytotherapy research 2002-03, Vol.16 (S1), p.45-50
Hauptverfasser:	Lu, Kuo-Liang, Tsai, Chin-Chuan, Ho, Li-Kang, Lin, Chun-Ching, Chang, Yuan-Shiun
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Naphthylisothiocyanate - toxicity Animals carbon tetrachloride Carbon Tetrachloride - toxicity Chemical and Drug Induced Liver Injury - prevention & control Dose-Response Relationship, Drug Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - therapeutic use Drugs, Chinese Herbal - toxicity hepatoprotective Ixeris laevigata var. oldhami Liver - drug effects Liver - enzymology Liver - pathology Liver Function Tests Male Medicine, Chinese Traditional Mice Mice, Inbred ICR Phytotherapy Plant Extracts - administration & dosage Plant Extracts - therapeutic use Plant Extracts - toxicity Plants, Medicinal Rats Rats, Wistar Silymarin - administration & dosage Silymarin - pharmacology Silymarin - therapeutic use Taiwan α -naphthylisothiocyanate
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Zusammenfassung:	The hepatoprotective effects of Ixeris laevigata Sch‐Bip. var. oldhami Kitam. (IL) were studied on cholestatic hepatitis induced by α‐naphthylisothiocyanate (ANIT, 100 mg/10 mL/kg, in olive oil, i.p.) and acute hepatitis induced by carbon tetrachloride (20% CCl4/olive oil, 1.5 mL/kg, i.p.) in rats. Hepatoprotective activity was monitored by estimating the serum transaminases levels and the histopathological changes in the livers of experimental rats. The pretreatment of animals with IL, extract (0.3–2.0 g/kg orally) significantly inhibited the acute elevation of serum transaminases, as well as the hepatotoxin‐induced histopathological changes in the livers of the experimental rats. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.801