Effects of aging on C57BL/6J mice: an electrophysiological and morphological study

Presbycusis is a progressive hearing loss associated with aging that manifests as deafness linked to cochlear morphological degeneration. The effects of aging on the auditory system were studied in C57BL/6J mice using electrophysiological (brainstem auditory evoked potentials; BAEP) and morphologica...

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Hauptverfasser:	Bartolomé, Maria Visitación, del, Castillo Eduardo, López, Lorena Maestre, Carricondo, Francisco, Poch-Broto, Joaquin, Gil-Loyzaga, Pablo
Format:	Buchkapitel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Cochlea - metabolism Cochlea - pathology Cochlea - physiopathology Evoked Potentials, Auditory, Brain Stem - physiology Glycoconjugates - metabolism Mice Mice, Inbred C57BL Organ of Corti - metabolism Organ of Corti - pathology Organ of Corti - physiopathology Presbycusis - metabolism Presbycusis - physiopathology
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Beschreibung
Zusammenfassung:	Presbycusis is a progressive hearing loss associated with aging that manifests as deafness linked to cochlear morphological degeneration. The effects of aging on the auditory system were studied in C57BL/6J mice using electrophysiological (brainstem auditory evoked potentials; BAEP) and morphological techniques. Cochleae of animals aged 1, 6, 9, 12, 15, 18, 21, or 24 months old were used for that purpose. The BAEP showed a progressive increase in latency and a reduction in amplitude. Morphological studies demonstrated total degeneration of the organ of Corti, which was replaced by a single epithelial layer. An affinity histochemistry study demonstrated minor modifications of glycoconjugates in the organ of Corti during the aging process.
ISSN:	0065-3071