Indole and β-Carboline Alkaloids from Geissospermum sericeum

The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these com...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2002-01, Vol.65 (1), p.85-88
Hauptverfasser:	STEELE, Jonathan C. P., VEITCH, Nigel C., KITE, Geoffrey C., SIMMONDS, Monique S. J., WARHURST, David C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Biological and medical sciences Brazil Carbolines - chemistry Carbolines - isolation & purification Carbolines - pharmacology Chloroquine - pharmacology Chromatography, Thin Layer Drug Resistance General pharmacology Humans Inhibitory Concentration 50 KB Cells - drug effects Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark - chemistry Plants, Medicinal - chemistry Plasmodium falciparum - drug effects Spectrophotometry, Ultraviolet Tumor Cells, Cultured - drug effects
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Zusammenfassung:	The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0101705