New Lanostanoids from the Mushroom Ganoderma lucidum

From a lipophilic extract of the fruiting body of Ganoderma lucidum, three new lanostanoids, 8beta,9alpha-dihydroganoderic acid J (1), methyl 8beta,9alpha-dihydroganoderate J (2), and 20-hydroxylganoderic acid G (3), along with 12 known lanostanoids and two ergostane sterols were isolated. The struc...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2002-01, Vol.65 (1), p.72-75
Hauptverfasser:	MA, Jiyuan, YE, Qing, HUA, Yanjun, ZHANG, Decheng, COOPER, Raymond, CHANG, Michael N., CHANG, Joseph Y., SUN, Hao H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, High Pressure Liquid Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Enzyme-Linked Immunosorbent Assay General pharmacology Humans Inhibitory Concentration 50 Interferon-gamma - analysis Interferon-gamma - blood Interleukin-2 - analysis Interleukin-2 - blood Interleukin-4 - analysis Interleukin-4 - blood Lanosterol - analogs & derivatives Lanosterol - chemistry Lanosterol - isolation & purification Lanosterol - pharmacology Leukocytes, Mononuclear - drug effects Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Reishi - chemistry Reishi - immunology Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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Beschreibung
Zusammenfassung:	From a lipophilic extract of the fruiting body of Ganoderma lucidum, three new lanostanoids, 8beta,9alpha-dihydroganoderic acid J (1), methyl 8beta,9alpha-dihydroganoderate J (2), and 20-hydroxylganoderic acid G (3), along with 12 known lanostanoids and two ergostane sterols were isolated. The structures of 1-3 were determined by interpretation of their spectroscopic data.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np010385e