Evaluation of interaction between valproate and baclofen in the formalin test in mice

Evaluation of interaction between valproate and baclofen in the formalin test in mice

Valproate and baclofen dose-dependently inhibited both phases of the formalin test. Combination of valproate and baclofen exerted the additive antinociceptive effect on both phases of the formalin test.

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Veröffentlicht in:Polish journal of pharmacology 2001-01, Vol.53 (1), p.51
Hauptverfasser: Czuczwar, M, Kiś, J, Swiader, M, Turski, W A, Przesmycki, K
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Baclofen - pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Female
GABA Agents - pharmacology
Mice
Pain Measurement - drug effects
Pain Threshold - drug effects
Valproic Acid - pharmacology
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Zusammenfassung:Valproate and baclofen dose-dependently inhibited both phases of the formalin test. Combination of valproate and baclofen exerted the additive antinociceptive effect on both phases of the formalin test.
ISSN:1230-6002