Molecular Cloning and Sequence Analysis of a Human Untranslated Alu-Containing RNA

Molecular Cloning and Sequence Analysis of a Human Untranslated Alu-Containing RNA

A cDNA, designated LNX1, has been identified by subtractive hybridization on the basis that it is expressed in normal human prostate but not in LNCaP cells. Sequence analysis revealed that it contained two Alu repetitive sequences but no long open reading frame. Hence, it belongs to a class of untra...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:DNA sequence 2001-01, Vol.12 (1), p.85-89
Hauptverfasser: Kwok, Simon C. M., Daskal, Ierachmiel
Format: Artikel
Sprache:eng
Schlagworte:
Alu Elements
Alu-containing RNA
Alu-repetitive sequence
Base Sequence
Chromosomes, Human, Pair 14 - genetics
Cloning, Molecular
DNA, Complementary - genetics
Female
Gene Expression
Humans
Male
Molecular Sequence Data
Pregnancy
Tissue Distribution
untranslated Alu-RNA
Untranslated Regions - genetics
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A cDNA, designated LNX1, has been identified by subtractive hybridization on the basis that it is expressed in normal human prostate but not in LNCaP cells. Sequence analysis revealed that it contained two Alu repetitive sequences but no long open reading frame. Hence, it belongs to a class of untranslated Alu-containing RNAs. LNX1 is expressed in most tissues. It is encoded by a single copy gene, which is localized on human chromosome 14.
ISSN:1042-5179
1029-2365
DOI:10.3109/10425170109042055