Status of chromosome breaks and gaps in breast cancer: a follow-up study

Genetic susceptibility and environmental factors are believed to be responsible for chromosomal instabilities and higher incidence of breast cancer. We conducted a follow-up study to find the levels of chromosome breaks and gaps in 20 premenopausal women with breast cancer before surgery, 1 month af...

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Veröffentlicht in:	Cancer genetics and cytogenetics 2001-10, Vol.130 (2), p.155-159
Hauptverfasser:	Ray, G.N, Shahid, M, Husain, S.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Biological and medical sciences Breast Neoplasms - diagnosis Breast Neoplasms - genetics Case-Control Studies Chromosome Aberrations Female Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged Premenopause Risk Factors Time Factors Tumors
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Zusammenfassung:	Genetic susceptibility and environmental factors are believed to be responsible for chromosomal instabilities and higher incidence of breast cancer. We conducted a follow-up study to find the levels of chromosome breaks and gaps in 20 premenopausal women with breast cancer before surgery, 1 month after surgery, and 3 years after surgery with respect to 20 age- and gender-matched controls. The mean level of chromosome breaks and gaps was found to be significantly higher ( P
ISSN:	0165-4608 1873-4456
DOI:	10.1016/S0165-4608(01)00482-4