Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation

Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98104 In the present study, we report the effects of adenosine receptor antagonists on pial vasodilatation during contralateral sciatic nerve stimulation (SNS). The pial circulation was observed through a closed cranial window in -chloralose-anesthetized rats. In artificial cerebrospinal fluid (CSF), SNS resulted in a 30.5 ± 13.2% increase in pial arteriolar diameter in the hindlimb somatosensory cortex. Systemic administration of the selective adenosine A 2A receptor antagonist, 4-(2-{7-amino-2-[2-furyl][3,2,4]triazolol[2,3-a][1,3,5]triazin-5-yl-amino} ethyl)phenol (ZM-241385), significantly ( P