Genome-wide scan for Parkinson's disease: The genePD Study

A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurology 2001-09, Vol.57 (6), p.1124-1126
Hauptverfasser:	DESTEFANO, A. L, GOLBE, L. I, LAFONTAINE, A. L, LABELLE, N, LEW, M. F, WATERS, C. H, GROWDON, J. H, SINGER, C, CURRIE, L. J, WOOTEN, G. F, VIEREGGE, P, PRAMSTALLER, P. P, MARK, M. H, KLEIN, C, HUBBLE, J. P, STACY, M, MONTGOMERY, E, MACDONALD, M. E, GUSELLA, J. F, MYERS, R. H, LAZZARINI, A. M, MAHER, N. E, SAINT-HILAIRE, M, FELDMAN, R. G, GUTTMAN, M, WATTS, R. L, SUCHOWERSKY, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 16 Chromosomes, Human, Pair 9 Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine beta-Hydroxylase - genetics Dystonia Musculorum Deformans - genetics Genetic Linkage - genetics Genetic Markers - genetics Genetic Testing Genome Humans Male Medical sciences Middle Aged Neurology Parkinson Disease - diagnosis Parkinson Disease - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.57.6.1124