Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review

1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and detection. 2. Developments have led to improvements in detection sensitivity, enhancements in specificity and increased capacity. 3. Emerging...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Xenobiotica 2001, Vol.31 (8-9), p.599-617
Hauptverfasser:	Plumb, R. S., Dear, G. J., Mallett, D. N., Higton, D. M., Pleasance, S., Biddlecombe, R. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Fluids - chemistry Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Humans Mass Spectrometry - instrumentation Mass Spectrometry - methods Pharmaceutical Preparations - analysis Robotics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and detection. 2. Developments have led to improvements in detection sensitivity, enhancements in specificity and increased capacity. 3. Emerging technologies such as monolithic column chromatography and miniaturized chip-based systems are discussed.
ISSN:	0049-8254 1366-5928
DOI:	10.1080/00498250110060941