Investigation of Follicular Penetration of Topically Applied Substances

The influence of specific follicle properties, sebum production and hair growth on the follicular penetration of topically applied substances was investigated. The behavior of follicles identified in selected skin areas of volunteers was analyzed by various tape stripping and staining methods in com...

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Veröffentlicht in:	Skin pharmacology and applied skin physiology 2001-01, Vol.14 (Suppl 1), p.17-22
Hauptverfasser:	Lademann, J., Otberg, N., Richter, H., Weigmann, H.-J., Lindemann, U., Schaefer, H., Sterry, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Biological and medical sciences Coloring Agents Cyanoacrylates General pharmacology Hair - growth & development Hair Follicle - metabolism Hair Follicle - secretion Humans Image Processing, Computer-Assisted Medical sciences Microscopy, Fluorescence Osmium Tetroxide Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Sebum - secretion Skin Absorption - physiology
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Zusammenfassung:	The influence of specific follicle properties, sebum production and hair growth on the follicular penetration of topically applied substances was investigated. The behavior of follicles identified in selected skin areas of volunteers was analyzed by various tape stripping and staining methods in combination with laser scanning microscopy. Furthermore hair growth in the selected skin areas was determined. A correlation between sebum production, hair growth activity and follicular penetration was observed.
ISSN:	1660-5527 1422-2868 1660-5535 1422-2906
DOI:	10.1159/000056385