Caerulein-induced pancreatitis in Wistar rats

We describe a refined model of intravenous caerulein-induced pancreatitis by using osmotic infusion pumps in the conscious unrestrained Wistar rat. The volume of caerulein required for the 6-h infusion is loaded into PE-55 catheter tubing attached to an Alzet (Alza Corporation, Palo Alto, CA) implan...

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Veröffentlicht in:	Contemporary topics in laboratory animal science 2000-07, Vol.39 (4), p.36
Hauptverfasser:	Farrant, G, Abu-Zidan, F M, Liu, X, Zwi, L J, Windsor, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ceruletide - administration & dosage Ceruletide - adverse effects Disease Models, Animal Infusions, Intravenous Male Osmosis Pancreatitis - chemically induced Pancreatitis - physiopathology Pancreatitis - veterinary Rats Rats, Wistar
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Zusammenfassung:	We describe a refined model of intravenous caerulein-induced pancreatitis by using osmotic infusion pumps in the conscious unrestrained Wistar rat. The volume of caerulein required for the 6-h infusion is loaded into PE-55 catheter tubing attached to an Alzet (Alza Corporation, Palo Alto, CA) implantable osmotic pump that has been primed with saline. The technique has reliably induced mild edematous pancreatitis, which we verified histologically. Our refined model has the advantages of unrestrained animals, reduced animal handling and acclimation, and decreased cost.
ISSN:	1060-0558