STRUCTURAL CHANGES IN THE KIDNEY INDUCED BY COARCTATION HYPERTENSION

We investigated structural alterations in renal tissue identifying the morphological and histological changes in the non-ischemic kidney (NIK) and their potential significance in aortic coarctation-hypertensive rats (HR). HR's mean arterial pressure (MAP) was higher compared with sham operated...

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Veröffentlicht in:	Clinical and experimental hypertension (1993) 2001, Vol.23 (6), p.501-511
Hauptverfasser:	Bruno, María Peral de, Turoni, Claudio M. Joo, Marañón, Rodrigo O., Reynoso, Héctor A., Coviello, Alfredo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - therapeutic use Aortic Coarctation - complications Aortic Coarctation - drug therapy Aortic Coarctation - physiopathology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Body Weight - physiology Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Disease Models, Animal Heart Rate - drug effects Histology, Comparative Hypertension Hypertension - complications Hypertension - drug therapy Hypertension - physiopathology Kidney Kidney - anatomy & histology Kidney - chemistry Kidney - drug effects Losartan - therapeutic use Male Medical sciences Organ Size - physiology Rats Rats, Inbred SHR Rats, Sprague-Dawley Renal Artery - physiopathology Renal vessels Renin-angiotensin system
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Beschreibung
Zusammenfassung:	We investigated structural alterations in renal tissue identifying the morphological and histological changes in the non-ischemic kidney (NIK) and their potential significance in aortic coarctation-hypertensive rats (HR). HR's mean arterial pressure (MAP) was higher compared with sham operated rats (SR). An oral 10 mg kg day losartan (LOS) dose diminished but not reverted MAP. Hypertrophy was noted in HR NIK's with significant weight increase (p< 0.01). The ratio IK NIK in HR's decreased 22% (p
ISSN:	1064-1963 1525-6006
DOI:	10.1081/CEH-100104241