C18orf2, a novel, highly conserved intronless gene within intron 5 of the GNAL gene on chromosome 18p11

We have characterized a novel intronless human gene (C18orf2) which is embedded in intron 5 of the G-protein gene (GNAL) on chromosome 18p11. This gene codes for a 199 amino acid polypeptide with a predicted molecular weight of 22.1 kDa. It is highly homologous to a number of predicted developmental...

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Veröffentlicht in:	Cytogenetic and genome research 2001-01, Vol.93 (1-2), p.19-22
Hauptverfasser:	Vuoristo, J.T., Berrettini, W.H., Ala-Kokko, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences C18orf2 gene chromosome 18 Chromosomes, Human, Pair 18 - genetics Classical genetics, quantitative genetics, hybrids Cloning, Molecular Conserved Sequence - genetics Expressed Sequence Tags Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Mapping, Cloning and Sequencing Genetics of eukaryotes. Biological and molecular evolution GNAL gene GTP-Binding Protein alpha Subunits Heterotrimeric GTP-Binding Proteins - genetics Human Humans Introns - genetics Molecular Sequence Data Open Reading Frames - genetics Physical Chromosome Mapping Polymerase Chain Reaction Promoter Regions, Genetic - genetics Proteins - chemistry Proteins - genetics RNA, Messenger - analysis RNA, Messenger - genetics Sequence Alignment Software
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Zusammenfassung:	We have characterized a novel intronless human gene (C18orf2) which is embedded in intron 5 of the G-protein gene (GNAL) on chromosome 18p11. This gene codes for a 199 amino acid polypeptide with a predicted molecular weight of 22.1 kDa. It is highly homologous to a number of predicted developmental proteins in organisms ranging from yeasts to Drosophila. C18orf2 mRNA was found to be expressed in various tissues.
ISSN:	1424-8581 0301-0171 1424-859X
DOI:	10.1159/000056940