ATP-mediated release of arachidonic acid metabolites from venular endothelium causes arteriolar dilation

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505 This study was designed to test the hypothesis that venular administration of ATP resulted in endothelium-dependent dilation of adjacent arterioles through a mechanism involving cycloox...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2001-06, Vol.280 (6), p.H2616-H2622
Hauptverfasser:	Hammer, Leah W, Ligon, Alison L, Hester, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - administration & dosage Adenosine Triphosphate - metabolism Animals Arachidonic Acid - metabolism Arterioles - drug effects Arterioles - physiology Cricetinae Cyclooxygenase Inhibitors - pharmacology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Indomethacin - pharmacology Infusions, Intravenous Male Mesocricetus Muscle, Skeletal - blood supply Prostaglandin-Endoperoxide Synthases - metabolism Vasodilation - drug effects Vasodilation - physiology Venules - drug effects Venules - metabolism
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Beschreibung
Zusammenfassung:	Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505 This study was designed to test the hypothesis that venular administration of ATP resulted in endothelium-dependent dilation of adjacent arterioles through a mechanism involving cyclooxygenase products. Forty-three male golden hamsters were anesthetized with pentobarbital sodium (60 mg/kg ip), and the cremaster muscle was prepared for in vivo microscopy. ATP (100 µM) injected into venules dilated adjacent arterioles from a mean diameter of 51 ± 4 to 76 ± 6 µm ( P
ISSN:	0363-6135 1522-1539
DOI:	10.1152/ajpheart.2001.280.6.h2616