Zinc modulation of GABA receptors expressed in Xenopus oocytes injected with carp brain poly(A)+ RNA

Two types of GABA receptors, GABAA receptors (approximately 85%) and GABAC-like receptors (approximately 15%), were expressed in Xenopus oocytes after injection of Poly(A)+ RNA with carp (Carassius carassius) brain. Using voltage-clamp technique and pharmacological methods, the effects of zinc on th...

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Veröffentlicht in:	Sheng li hsüeh pao 1998-06, Vol.50 (3), p.268
Hauptverfasser:	Bai, X C, Bao, Y D
Format:	Artikel
Sprache:	chi
Schlagworte:	Animals Brain - metabolism Carps Female Oocytes - metabolism Receptors, GABA - biosynthesis Receptors, GABA-B - biosynthesis RNA, Messenger - metabolism Transfection Xenopus laevis Zinc - pharmacology
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description	Two types of GABA receptors, GABAA receptors (approximately 85%) and GABAC-like receptors (approximately 15%), were expressed in Xenopus oocytes after injection of Poly(A)+ RNA with carp (Carassius carassius) brain. Using voltage-clamp technique and pharmacological methods, the effects of zinc on the two receptors were studied. It was found that zinc modulation of both GABAA and GABAC-like receptors by zinc was inhibitory and reversible with the former being stronger than the latter as indicated by a value of IC50 of 48.4 +/- 10.1 mumol/L against 255.6 +/- 21.5 mumol/L.
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It was found that zinc modulation of both GABAA and GABAC-like receptors by zinc was inhibitory and reversible with the former being stronger than the latter as indicated by a value of IC50 of 48.4 +/- 10.1 mumol/L against 255.6 +/- 21.5 mumol/L.</description><identifier>ISSN: 0371-0874</identifier><identifier>PMID: 11324566</identifier><language>chi</language><publisher>China</publisher><subject>Animals ; Brain - metabolism ; Carps ; Female ; Oocytes - metabolism ; Receptors, GABA - biosynthesis ; Receptors, GABA-B - biosynthesis ; RNA, Messenger - metabolism ; Transfection ; Xenopus laevis ; Zinc - pharmacology</subject><ispartof>Sheng li hsüeh pao, 1998-06, Vol.50 (3), p.268</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11324566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bai, X C</creatorcontrib><creatorcontrib>Bao, Y D</creatorcontrib><title>Zinc modulation of GABA receptors expressed in Xenopus oocytes injected with carp brain poly(A)+ RNA</title><title>Sheng li hsüeh pao</title><addtitle>Sheng Li Xue Bao</addtitle><description>Two types of GABA receptors, GABAA receptors (approximately 85%) and GABAC-like receptors (approximately 15%), were expressed in Xenopus oocytes after injection of Poly(A)+ RNA with carp (Carassius carassius) brain. Using voltage-clamp technique and pharmacological methods, the effects of zinc on the two receptors were studied. 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Using voltage-clamp technique and pharmacological methods, the effects of zinc on the two receptors were studied. It was found that zinc modulation of both GABAA and GABAC-like receptors by zinc was inhibitory and reversible with the former being stronger than the latter as indicated by a value of IC50 of 48.4 +/- 10.1 mumol/L against 255.6 +/- 21.5 mumol/L.</abstract><cop>China</cop><pmid>11324566</pmid></addata></record>
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subjects	Animals Brain - metabolism Carps Female Oocytes - metabolism Receptors, GABA - biosynthesis Receptors, GABA-B - biosynthesis RNA, Messenger - metabolism Transfection Xenopus laevis Zinc - pharmacology
title	Zinc modulation of GABA receptors expressed in Xenopus oocytes injected with carp brain poly(A)+ RNA
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