Zinc modulation of GABA receptors expressed in Xenopus oocytes injected with carp brain poly(A)+ RNA

Zinc modulation of GABA receptors expressed in Xenopus oocytes injected with carp brain poly(A)+ RNA

Two types of GABA receptors, GABAA receptors (approximately 85%) and GABAC-like receptors (approximately 15%), were expressed in Xenopus oocytes after injection of Poly(A)+ RNA with carp (Carassius carassius) brain. Using voltage-clamp technique and pharmacological methods, the effects of zinc on th...

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Veröffentlicht in:Sheng li hsüeh pao 1998-06, Vol.50 (3), p.268
Hauptverfasser: Bai, X C, Bao, Y D
Format: Artikel
Sprache:chi
Schlagworte:
Animals
Brain - metabolism
Carps
Female
Oocytes - metabolism
Receptors, GABA - biosynthesis
Receptors, GABA-B - biosynthesis
RNA, Messenger - metabolism
Transfection
Xenopus laevis
Zinc - pharmacology
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Zusammenfassung:Two types of GABA receptors, GABAA receptors (approximately 85%) and GABAC-like receptors (approximately 15%), were expressed in Xenopus oocytes after injection of Poly(A)+ RNA with carp (Carassius carassius) brain. Using voltage-clamp technique and pharmacological methods, the effects of zinc on the two receptors were studied. It was found that zinc modulation of both GABAA and GABAC-like receptors by zinc was inhibitory and reversible with the former being stronger than the latter as indicated by a value of IC50 of 48.4 +/- 10.1 mumol/L against 255.6 +/- 21.5 mumol/L.
ISSN:0371-0874