Macrocytosis in Patients on Stavudine

We retrospectively reviewed the effects on the erythrocyte mean corpuscular volume (MCV) of the use of stavudine - including antiretroviral regimens in both zidovudine-naive and zidovudine-experienced HIV-infected patients. Macrocytosis was commonly observed among patients on stavudine-based regimen...

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Veröffentlicht in:	Scandinavian journal of infectious diseases 2001, Vol.33 (3), p.239-240
Hauptverfasser:	EYER-SILVA, Walter A, ARABE, Jucara, PINTO, Jorge Francisco C, MORAIS-DE-SA, Carlos Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Macrocytic - chemically induced Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Biological and medical sciences Cohort Studies Drug toxicity and drugs side effects treatment Erythrocyte Indices - drug effects Female HIV Infections - blood HIV Infections - drug therapy Human immunodeficiency virus 1 Humans Male Medical sciences Pharmacology. Drug treatments Retrospective Studies Stavudine Stavudine - adverse effects Stavudine - therapeutic use Toxicity: blood Tropical medicine
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Zusammenfassung:	We retrospectively reviewed the effects on the erythrocyte mean corpuscular volume (MCV) of the use of stavudine - including antiretroviral regimens in both zidovudine-naive and zidovudine-experienced HIV-infected patients. Macrocytosis was commonly observed among patients on stavudine-based regimens although the MCV usually stabilized at a lower level than that observed with zidovudine.
ISSN:	0036-5548 1651-1980
DOI:	10.1080/00365540151061067