Carcinogenicity of Three Dose Levels of 1,4-Bis(4-fluorophenyl)-2-propynyl-N-cyclooctyl Carbamate in Male Sprague-Dawley and F344 Rats

Feeding 1,4-bis(4-fluorophenyl)-2-propynyl-N-cyclooctyl carbamate to F344 or Sprague-Dawley male rats at 125-500 ppm in the diet led to many carcinomas of the small intestine and ear duct (Zymbal's gland tumors) in addition to lymphomas and leukemias. A high incidence of mammary adenocarcinomas...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1975-04, Vol.54 (4), p.975-979
Hauptverfasser:	Weisburger, E K, Ulland, B M, Schueler, R L, Weisburger, J H, Harris, P N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemically induced Adenocarcinoma - pathology Animals Carbamates - toxicity Carcinogens Colonic Neoplasms - chemically induced Diet Ear Neoplasms - chemically induced Genotype Intestinal Neoplasms - chemically induced Leukemia, Experimental - chemically induced Liver Neoplasms - chemically induced Lymphoma - chemically induced Male Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - pathology Neoplasms, Experimental - chemically induced Rats
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Zusammenfassung:	Feeding 1,4-bis(4-fluorophenyl)-2-propynyl-N-cyclooctyl carbamate to F344 or Sprague-Dawley male rats at 125-500 ppm in the diet led to many carcinomas of the small intestine and ear duct (Zymbal's gland tumors) in addition to lymphomas and leukemias. A high incidence of mammary adenocarcinomas was found in the Sprague-Dawley rats. Only a few colon or liver tumors were observed in each strain.
ISSN:	0027-8874 1460-2105
DOI:	10.1093/jnci/54.4.975