Angiotensin II–Induced Hypertension in Bradykinin B2 Receptor Knockout Mice

The present study was performed to examine the role of endogenous bradykinin (BK) in the development of angiotensin II (Ang II)–induced hypertension in mice. BK B2 receptor knockout (B2R) and wild-type (B2R) mice (22 to 26 g) were infused with either saline (SAL) or Ang II (40 ng/min) via an osmotic...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-03, Vol.37 (3), p.967-973
Hauptverfasser:	Cervenka, Ludek, Malý, Jan, Karasová, Ludmila, Simová, Marcela, Vítko, Stefan, Hellerová, Sona, Heller, Jirí, El-Dahr, Samir S
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Body Weight Cardiology. Vascular system Experimental diseases Glomerular Filtration Rate Hypertension - chemically induced Infusion Pumps, Implantable Medical sciences Mice Mice, Knockout Nitric Oxide Synthase - antagonists & inhibitors Norepinephrine - pharmacology Organ Size Receptor, Bradykinin B2 Receptors, Bradykinin - deficiency Receptors, Bradykinin - genetics Renal Circulation Time Factors Vasoconstriction
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Zusammenfassung:	The present study was performed to examine the role of endogenous bradykinin (BK) in the development of angiotensin II (Ang II)–induced hypertension in mice. BK B2 receptor knockout (B2R) and wild-type (B2R) mice (22 to 26 g) were infused with either saline (SAL) or Ang II (40 ng/min) via an osmotic minipump implanted intraperitoneally. On day 12 after implantation, there was no difference in systolic blood pressure (SBP, tail-cuff plethysmography) between SAL/B2R and SAL/B2R mice (128±5 versus 133±6 mm Hg, n=24/group). In contrast, SBP was higher on day 12 of infusion in Ang II/B2R than in Ang II/B2R mice (173±6 versus 156±5 mm Hg;P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.hyp.37.3.967