Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, interferon-γ production, and expansion of natural killer cells

We investigated the in vitro effects of combining interleukin-18 (IL-18) and IL-2 on human lymphocytes. The combined use of these two cytokines synergistically enhanced the proliferation, cytolytic activity, and interferon-gamma production of peripheral blood mononuclear cells. Phenotypic analysis r...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2001-02, Vol.61 (3), p.884-888
Hauptverfasser:	SON, Young-Ik, DALLAL, Ramsey M, MAILLIARD, Robbie B, EGAWA, Shinichi, JONAK, Zdenka L, LOTZE, Michael T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Division - drug effects Cytotoxicity, Immunologic - drug effects Drug Synergism Humans Immunotherapy Interferon-gamma - biosynthesis Interleukin-18 - pharmacology Interleukin-2 - pharmacology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocyte Activation - drug effects Lymphocytes - drug effects Lymphocytes - immunology Lymphocytes - metabolism Lymphoma, B-Cell - immunology Medical sciences Pharmacology. Drug treatments Receptors, Interleukin-2 - biosynthesis Tumor Cells, Cultured Up-Regulation - drug effects
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Zusammenfassung:	We investigated the in vitro effects of combining interleukin-18 (IL-18) and IL-2 on human lymphocytes. The combined use of these two cytokines synergistically enhanced the proliferation, cytolytic activity, and interferon-gamma production of peripheral blood mononuclear cells. Phenotypic analysis revealed a preferential expansion of CD56+CD3- cells and an up-regulation of IL-2 receptor-alpha expression on natural killer cells. Isolated natural killer cells showed a substantial increase in proliferation and cytotoxicity compared with CD4+ and CD8+ T cells. The combined use of IL-18 and IL-2 should be considered a viable strategy to induce an antitumor response in vivo.
ISSN:	0008-5472 1538-7445