Pathomorphological characteristics of experimental toxemia induced by thermostable Yersinia pseudotuberculosis toxin

Pathogenic properties of thermostable toxin responsible for pathogenicity of Yersinia pseudotuberculosis were experimentally studied. The toxin exerted a pronounced polyorgan cytopathogenic effect with predominating degenerative destructive changes and membranolytic effect on cell ultrastructure of...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2000-11, Vol.130 (11), p.1123
Hauptverfasser:	Isachkova, L M, Timchenko, N F, Nedashkovskaya, E P, Raznik, S D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Toxins - administration & dosage Bacterial Toxins - toxicity Capillaries - drug effects Capillaries - pathology Disease Models, Animal Enterotoxins - administration & dosage Enterotoxins - toxicity Gallbladder - drug effects Gallbladder - pathology Heart - drug effects Kidney - drug effects Kidney - pathology Liver - drug effects Liver - pathology Lung - drug effects Lung - pathology Mice Myocardium - pathology Spleen - drug effects Spleen - pathology Toxemia - pathology Yersinia pseudotuberculosis
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Zusammenfassung:	Pathogenic properties of thermostable toxin responsible for pathogenicity of Yersinia pseudotuberculosis were experimentally studied. The toxin exerted a pronounced polyorgan cytopathogenic effect with predominating degenerative destructive changes and membranolytic effect on cell ultrastructure of parenchymatous organs. The toxin is believed to be directly involved in the development of typical pathomorphological picture of pseudotuberculosis, which confirms its pathogenetic role.
ISSN:	0007-4888
DOI:	10.1023/A:1002872407532