Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue

Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue

1. Exogenous ATP produces acute and localized pain in humans, and P2X receptor agonists elicit acute nociceptive behaviours in rodents following intradermal administration to the hindpaw. The predominant localization of P2X(3) mRNA in sensory neurones has led to the hypothesis that activation of P2X...

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Veröffentlicht in:British journal of pharmacology 2001-01, Vol.132 (1), p.259
Hauptverfasser: Jarvis, M F, Wismer, C T, Schweitzer, E, Yu, H, van Biesen T, Lynch, K J, Burgard, E C, Kowaluk, E A
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Triphosphate - analogs & derivatives
Adenosine Triphosphate - pharmacology
Animals
Dose-Response Relationship, Drug
Fluorescent Dyes
Formaldehyde
Immunohistochemistry
Injections, Intradermal
Male
Pain - chemically induced
Pain - physiopathology
Pain Measurement
Purinergic P2 Receptor Antagonists
Rats
Rats, Sprague-Dawley
Receptors, Purinergic P2X3
Triazines - pharmacology
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Zusammenfassung:1. Exogenous ATP produces acute and localized pain in humans, and P2X receptor agonists elicit acute nociceptive behaviours in rodents following intradermal administration to the hindpaw. The predominant localization of P2X(3) mRNA in sensory neurones has led to the hypothesis that activation of P2X(3) and/or P2X(2/3) receptors contributes to nociception. 2. The local administration of the P2X receptor agonist, BzATP (100--1000 nmol paw(-1), s.c.) into the rat hindpaw produced an acute (
ISSN:0007-1188
DOI:10.1038/sj.bjp.0703793