Oral contraceptives can cause falsely low vitamin B(12) levels

Serum vitamin B(12) radioimmunoassays may give falsely low results in patients with folate deficiency, multiple myeloma, megadose of vitamin C and following radioisotope organ scan. We evaluated 10 consecutive healthy women on oral contraceptives (OC) who had falsely low vitamin B(12) levels, as ref...

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Veröffentlicht in:	Acta haematologica 2000, Vol.104 (1), p.22
Hauptverfasser:	Gardyn, J, Mittelman, M, Zlotnik, J, Sela, B A, Cohen, A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Contraceptives, Oral - administration & dosage Contraceptives, Oral - adverse effects Contraceptives, Oral - blood Diagnostic Errors False Positive Reactions Female Homocysteine - blood Humans Methylmalonic Acid - urine Transcobalamins - drug effects Transcobalamins - metabolism Vitamin B 12 Deficiency - diagnosis Vitamin B 12 Deficiency - etiology
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Zusammenfassung:	Serum vitamin B(12) radioimmunoassays may give falsely low results in patients with folate deficiency, multiple myeloma, megadose of vitamin C and following radioisotope organ scan. We evaluated 10 consecutive healthy women on oral contraceptives (OC) who had falsely low vitamin B(12) levels, as reflected by normal urine methylmalonic acid and plasma homocysteine. After 1-month cessation of OCs, vitamin B(12) returned to the normal range in all women. Transcobalamin I (TCI) blood level was decreased in 60% of patients. OCs may cause temporary low vitamin B(12) blood levels of no clinical significance that can be associated with low TCI levels
ISSN:	0001-5792