Effects of exercise training on cardiac function, gene expression, and apoptosis in rats
1 Department of Cardiovascular Research and 2 Department of Pathology, Genentech Incorporated, South San Francisco, California 94080 This study determined the effects of exercise training on cardiac function, gene expression, and apoptosis. Rats exposed to a regimen of treadmill exercise for 13 wk...
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Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2000-12, Vol.279 (6), p.H2994-H3002 |
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Zusammenfassung: | 1 Department of Cardiovascular Research and
2 Department of Pathology, Genentech Incorporated, South San
Francisco, California 94080
This study determined the effects of
exercise training on cardiac function, gene expression, and apoptosis.
Rats exposed to a regimen of treadmill exercise for 13 wk had a
significant increase in cardiac index and stroke volume index and a
concomitant decrease in systemic vascular resistance compared with both
age-matched and body weight-matched sedentary controls in the conscious
state at rest. In exercise-trained animals, there was no change in the expression of several marker genes known to be associated with pathological cardiac adaptation, including atrial natriuretic factor,
-myosin heavy chain, -skeletal and smooth muscle actins, and
collagens I and III. Exercise training, however, produced a significant
induction of -myosin heavy chain, which was not observed in rats
with myocardial infarction. No histological features of cardiac
apoptosis were observed in the treadmill-trained rats. In contrast,
apoptotic myocytes were detected in animals with myocardial infarction.
In summary, exercise training improves cardiac function without
evidence of cardiac apoptosis and produces a pattern of cardiac gene
expression distinct from pathological cardiac adaptation.
treadmill; hemodynamics; physiological loads; pathological loads; myocardial infarction |
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ISSN: | 0363-6135 1522-1539 |
DOI: | 10.1152/ajpheart.2000.279.6.h2994 |