Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tü 6040: I. Taxonomy, Fermentation, Isolation and Biological Activities

Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tü 6040 by HFLC-diode-array and HPLCelectrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic...

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Veröffentlicht in:	Journal of antibiotics 2000/08/25, Vol.53(8), pp.779-787
Hauptverfasser:	SCHIMANA, JUDITH, FIEDLER, HANS-PETER, GROTH, INGRID, SUBMUTH, RODERICK, BEIL, WINFRIED, WALKER, MARTINA, ZEECK, AXEL
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, Antineoplastic - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chemotherapic agents Coumarins - isolation & purification Coumarins - metabolism Coumarins - pharmacology Drug Screening Assays, Antitumor Fermentation Fundamental and applied biological sciences. Psychology Glycosides - isolation & purification Glycosides - metabolism Glycosides - pharmacology Humans Inhibitory Concentration 50 Microbial Sensitivity Tests Microbiology Streptomyces antibioticus - classification Streptomyces antibioticus - metabolism Tumor Cells, Cultured
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Zusammenfassung:	Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tü 6040 by HFLC-diode-array and HPLCelectrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.53.779