Gd-DTPA relaxivity depends on macromolecular content

Gd-DTPA T(1) relaxivity of water protons was measured at 1.5 T and room temperature as a function of macromolecular content in model systems. Gd-DTPA relaxivity was found to increase with macromolecular concentration. The results of this study indicate that the Gd-DTPA relaxivity in tissue extracell...

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Veröffentlicht in:Magnetic resonance in medicine 2000-11, Vol.44 (5), p.665
Hauptverfasser: Stanisz, G J, Henkelman, R M
Format: Artikel
Sprache:eng
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Zusammenfassung:Gd-DTPA T(1) relaxivity of water protons was measured at 1.5 T and room temperature as a function of macromolecular content in model systems. Gd-DTPA relaxivity was found to increase with macromolecular concentration. The results of this study indicate that the Gd-DTPA relaxivity in tissue extracellular compartment could be as much as 30-70% higher than that of Gd-DTPA in saline. Quantitative MR analyses that use T(1) as an estimation of local Gd-DTPA concentration require a priori determination of the Gd relaxivity in tissue.
ISSN:0740-3194
DOI:10.1002/1522-2594(200011)44:5<665::AID-MRM1>3.3.CO;2-D